NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin

Katarkar, Bottoni et al., Nature Communication, 2020

We have been focusing on the interconnection between skin aging and development of skin “cancer fields”, i.e. multiple and recurrent cancer lesions linked with chronic sun exposure and patients’ immune suppression. Our findings point to the existence of stromal cells genetic alterations with potential therapeutic implications.