Program
[/et_pb_text][et_pb_accordion _builder_version=”4.5.1″ _module_preset=”default” hover_enabled=”0″ custom_margin=”41px|||||”][et_pb_accordion_item open=”on” _builder_version=”4.5.1″ _module_preset=”default” custom_css_main_element=”display:none;”][/et_pb_accordion_item][et_pb_accordion_item title=”Session I” _builder_version=”4.5.1″ _module_preset=”default” hover_enabled=”0″ open=”off”]16:00-16:15
Welcome address by G. Paolo Dotto
International Cancer Prevention Institute (ICPI), Massachusetts General Hospital (MGH), USA and Université de Lausanne (UNIL), Switzerland
Session I: On human populations, genes and evolution
Chair: Gian-Paolo Dotto
16:15-17:00
Opening Keynote lecture: Mechanisms of protection by HPV vaccination
Doug Lowy – BOOK
National Cancer Institute, USA
17:00-17:30
Genetic and environmental contributions to cancer development: lessons from the mouse
Allan Balmain – BOOK
University of California San Francisco, USA
17:30-18:00
Break
18:00-18:30
Race and gender differences in skin cancer susceptibility
Berna Özdemir / Xiaoying Xu
International Cancer Prevention Institute (ICPI) & Centre Hospitalier Universitaire Vaudois (CHUV), Switzerland / Université de Lausanne (UNIL), Switzerland
18:30-19:00
Diseases of the skin in the light of recent human evolution
Tony Capra
Vanderbilt University, USA
19:00-20:00
Welcome drinks
20:00
Dinner
[/et_pb_accordion_item][et_pb_accordion_item title=”Session II” _builder_version=”4.5.1″ _module_preset=”default” hover_enabled=”0″ open=”off”]Session II: At the beginning
Chair: Sabine Werner & Erwin Wagner
8:30-9:00
Cellular senescence, aging and skin cancer
Judith Campisi
Buck Institute, USA
9:00-9:15
Inhibition of mitotic kinases cdk1 or PlK1 in skin and oral epithelia triggers a squamous differentiation response ensuring genome integrity
Natalia Sanz-Gómez
Instituto de Investigación Marqués de Valdecilla (IDIVAL), Spain
9:15-9:45
Dyskeratosis congenita and telomere biology disorders as models for understanding cancer etiology
Sharon A. Savage
National Institutes of Health (NIH), USA
9:45-10:00
Driver mutations and signatures of mutational processes in two brothers suffering from nevoid basal cell carcinoma syndrome
Omar Hasan Ali
Department of Dermatology, Zurich University Hospital, Switzerland
10:00-10:30
Coffee break
10:30-11:00
Understanding the molecular basis of non-melanoma skin cancer
Irene Leigh
University of Dundee, Scotland
11:00-11:15
Cell of origin determines mutational signature and invasiveness of sebaceous carcinoma
Raymond Cho
University of California, San Francisco
11:15-11:20
Inorganic Nanozyme cerium oxide potentially reduces the UV induced oxidative damage in skin
Aditya Arya
Pathfinder Research and Training Foundation, India
11:20-11:25
RIPK4 maintains epidermal homeostasis and prevents skin cancer by suppressing mitogenic signaling
Giel Tanghe
VIB – University Ghent, Belgium
11:25-11:30
Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B
Dania Al Labban
11:30-11:45
PI3K/AKT induced differentiation is a dominant tumor suppressive mechanism that restrains clonal expansion in skin epithelium
Slobodan Beronja
Fred Hutchinson Cancer Research Center, USA
11:45-12:00
Selective transcriptional programs downstream of p63 and p73 in early stages of skin squamous cell carcinoma
Caterina Missero/Dario Antonini
University of Naples Federico II, Italy
12:00-12:30
How p53 mutant stem cells colonize the epidermis
Phil Jones
Sanger Institute, UK
12:30-16:00
Lunch and poster session I
[/et_pb_accordion_item][et_pb_accordion_item title=”Session III” _builder_version=”4.5.1″ _module_preset=”default” hover_enabled=”0″ open=”off”]Session III: Under the surface
Chair: Irene Leigh & Raymond Cho
16:00-16:30
Non-deletional mechanisms of cancer control
Martin Röcken
University of Tübingen, Germany
16:30-16:45
Differential role of the rasgefs sos1 and sos2 in mouse skin homeostasis and carcinogenesis
Fernando Calvo Baltanas
Centro de Investigación del Cancer-IBMCC, Spain
16:45-17:00
p53 regulated long non-coding RNA LINC00346 promotes cutaneous squamous cell carcinoma progression by regulating STAT3 and matrix metalloproteinase expression
Minna Piipponen
University of Turku, Finland
17:00-17:30
Chronic inflammation and skin disease
Erwin Wagner
Centro Nacional de Investigaciones Oncológicas (CNIO), Spain
17:30-18:00
Break
18:00-18:30
Factors controlling stromal functions in wound healing and skin cancer
Sabine Werner
Eidgenössische Technische Hochschule Zurich (ETH), Switzerland
18:30-18:45
Roles of the nuclear receptors PPARs in skin responses to UV and skin cancers
Liliane Michalik
University of Lausanne (UNIL), Switzerland
18:45-18:50
CSL / Notch1 control genomic stability in cancer-associated fibroblast activation and expansion
Giulia Bottoni
University of Lausanne (UNIL), Switzerland & Massachusetts General Hospital (MGH), USA
18:50-18:55
Targeting Activin signaling pathway in SCC
Michael Cangkrama
Eidgenössische Technische Hochschule Zurich (ETH), Switzerland
18:55-19:00
Efficient cancer control with immune checkpoint blockade requires cytokine-induced senescence
Ellen Brenner
Dermatology, Eberhard Karls University Tübingen, Germany
19:00-19:30
An important role of the vasculature in skin cancer progression
Michael Detmar
Eidgenössische Technische Hochschule Zurich (ETH), Switzerland
20:00
Dinner
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Session IV: The pigment cell enigma
Chair: Martin Röcken & Liliane Michalik
08:30-09:00
Time and space trends in melanoma incidence and mortality: clues for understanding the etiology
Roberto Zanetti
International Association of Cancer Registries (IACR)
09:00-09:15
Reproductive factors, exogenous hormone use, and incidence of melanoma among women in the United States
Elizabeth Cahoon
U.S. National Cancer Institute, USA
09:15-09:45
Mechanisms underlying risk and pathogenesis of melanoma
David Fisher
Massachusetts General Hospital (MGH), USA
09:45-10:00
Subpopulations of melanoma cells with distinct biological properties exhibit varying levels of ZEB proteins
Niels Vandamme
VIB – Inflammation Research Center, Belgium
10:00-10:30
Coffee break
10:30-11:00
Humanized mice: A model for melanocyte transformation and early melanoma progression
Shyam Somasundaram
The Wistar Institute, USA
11:00-11:30
Melanomas and their precursors
Boris Bastian
University of California San Francisco, USA
11:30-11:35
BRAFV600E in Primary and Recurrent Nevi and Melanomas
Nora Woltsche
Medical University of Graz, Austria
11:35-11:40
Spontaneous and therapeutic STING activation in the skin melanoma microenvironment induces an efficient antitumor immune response
Dorys Adriana Lopez Ramos
Centre Hospitalier Universitaire Vaudois (CHUV), Switzerland
11:40-11:45
Unexpected contribution of lymphatic vessels to promotion of distant metastatic spread of melanoma
Qiaoli Ma
Eidgenössische Technische Hochschule Zurich (ETH), Switzerland
11:45-12:15
Clinical Raster Scan Optoacoustic Mesoscopy for skin imaging. Diving deep and staying focused
Juan Aguirre
Technische Universität München and Institute for Biological and Medical Imaging, Helmholtz Zentrum München, Germany
12:15-12:30
Comprehensively characterize complex tissues in spatial context with Imaging Mass Cytometry
Roberto Spada
Fluidigm
12:30-16:00
Lunch and poster session II
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Session V: The interplay between immune cells and their neighbours
Chair: Maria Sibilia & Caterina Missero
16:00-16:30
Molecular changes in Actinic Keratosis and effects of treatment with photodynamic therapy
Francesca Zolezzi
GALDERMA
16:30-17:00
The impact of neutrophils in cutaneous leishmaniasis
Fabienne Tacchini-Cottier
University of Lausanne
17:00-17:30
Immune influences on early mutant keratinocyte clonal expansion
Michael Girardi
Yale School of Medicine, USA
17:30-18:00
Break
18:00-18:30
Key functional genomic events in the transformation of cutaneous T-cells
Sean Whittaker
King’s College London, UK
18:30-18:45
Epithelial damage and tissue gd T cells promote a unique tumor- protective IgE response
Jessica Strid
Imperial College London, UK
18:45-18:50
Simultaneous Multiplexed Imaging of mRNA and Proteins with Subcellular Resolution in Tissue Samples by Imaging Mass Cytometry
Daniel Schulz
Institute of Molecular Life Sciences/University of Zurich, Switzerland
18:50-19:20
Essential role of skin commensal bacteria in the wound healing response
Michel Gilliet
Centre Hospitalier Universitaire Vaudois – Université de Lausanne (CHUV-UNIL), Switzerland
20:00
Dinner and drinks
[/et_pb_accordion_item][et_pb_accordion_item title=”Session VI” _builder_version=”4.5.1″ _module_preset=”default” hover_enabled=”0″ open=”off”]Session VI: The skin ecosystem
Chair: Allan Balmain & Berna Özdemir
08:30-09:00
The influence of skin microbiota to skin inflammation
Maria Sibilia
Medical University of Vienna, Austria
09:00-09:15
UV and Cutaneous Papillomavirus Infection cooperate in Non-Melanoma Skin Cancer Development
Daniel Hasche
German Cancer Research Center (DKFZ), Germany
09:15-09:30
Melanoma-derived extracellular microvesicles are taken up by lymph node resident macrophages and lymphatic endothelial cells and induce lymph node remodeling
Lothar Dieterich
Eidgenössische Technische Hochschule Zurich (ETH), Switzerland
09:30-10:00
Role for the skin microbiota in tissue immunity and inflammation
Yasmine Belkaid
National Institutes of Health (NIH), USA
10:00-10:30
Coffee break
10:30-11:00
Role of the microenvironment in cancer invasion and therapy response
Erik Sahai
The Francis Crick Institute
11:00-11:15
Pitx1 controls a bi-stable transcriptional network that governs self-renewal and differentiation in Squamous Cell Carcinomas
Markus Schober
NYU School of Medicine, Department of Dermatology, USA
11:15-11:45
Highly multiplexed analysis of the tumor ecosystem on the single cell level by mass cytometry
Bernd Bodenmiller
Institute of Molecular Life Sciences, University of Zürich, Switzerland
11:45-12:00
Skin Cancer Prevention: meeting highlights and a look into the future
Barbara Gilchrest
Massachusetts General Hospital (MGH), USA
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