Perspectives on skin cancer prevention

08 – 11 April 2018 | Les Diablerets, Switzerland

Program

Session I

16:00-16:15

Welcome address by G. Paolo Dotto

International Cancer Prevention Institute (ICPI), Massachusetts General Hospital (MGH), USA and Université de Lausanne (UNIL), Switzerland

Session I: On human populations, genes and evolution

Chair: Gian-Paolo Dotto

16:15-17:00

Opening Keynote lecture: Mechanisms of protection by HPV vaccination

Doug Lowy     BOOK

National Cancer Institute, USA

17:00-17:30

Genetic and environmental contributions to cancer development: lessons from the mouse

Allan Balmain  – BOOK

University of California San Francisco, USA

17:30-18:00

Break

18:00-18:30

Race and gender differences in skin cancer susceptibility

Berna Özdemir / Xiaoying Xu

International Cancer Prevention Institute (ICPI) & Centre Hospitalier Universitaire Vaudois (CHUV), Switzerland / Université de Lausanne (UNIL), Switzerland

18:30-19:00

Diseases of the skin in the light of recent human evolution

Tony Capra

Vanderbilt University, USA

19:00-20:00

Welcome drinks

20:00

Dinner

Session II

Session II: At the beginning

Chair: Sabine Werner & Erwin Wagner

8:30-9:00

Cellular senescence, aging and skin cancer

Judith Campisi

Buck Institute, USA

9:00-9:15

Inhibition of mitotic kinases cdk1 or PlK1 in skin and oral epithelia triggers a squamous differentiation response ensuring genome integrity

Natalia Sanz-Gómez

Instituto de Investigación Marqués de Valdecilla (IDIVAL), Spain

9:15-9:45

Dyskeratosis congenita and telomere biology disorders as models for understanding cancer etiology

Sharon A. Savage

National Institutes of Health (NIH), USA

9:45-10:00

Driver mutations and signatures of mutational processes in two brothers suffering from nevoid basal cell carcinoma syndrome 

Omar Hasan Ali

Department of Dermatology, Zurich University Hospital, Switzerland

10:00-10:30

Coffee break

10:30-11:00

Understanding the molecular basis of non-melanoma skin cancer

Irene Leigh

University of Dundee, Scotland

11:00-11:15

Cell of origin determines mutational signature and invasiveness of sebaceous carcinoma

Raymond Cho

University of California, San Francisco

11:15-11:20

Inorganic Nanozyme cerium oxide potentially reduces the UV induced oxidative damage in skin

Aditya Arya

Pathfinder Research and Training Foundation, India

11:20-11:25

RIPK4 maintains epidermal homeostasis and prevents skin cancer by suppressing mitogenic signaling

Giel Tanghe

VIB – University Ghent, Belgium

11:25-11:30

Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B

Dania Al Labban

11:30-11:45

PI3K/AKT induced differentiation is a dominant tumor suppressive mechanism that restrains clonal expansion in skin epithelium

Slobodan Beronja

Fred Hutchinson Cancer Research Center, USA

11:45-12:00

Selective transcriptional programs downstream of p63 and p73 in early stages of skin squamous cell carcinoma

Caterina Missero/Dario Antonini

University of Naples Federico II, Italy

12:00-12:30

How p53 mutant stem cells colonize the epidermis

Phil Jones

Sanger Institute, UK

12:30-16:00

Lunch and poster session I

Session III

Session III: Under the surface

Chair: Irene Leigh & Raymond Cho

16:00-16:30

Non-deletional mechanisms of cancer control

Martin Röcken

University of Tübingen, Germany

16:30-16:45

Differential role of the rasgefs sos1 and sos2 in mouse skin homeostasis and carcinogenesis

Fernando Calvo Baltanas

Centro de Investigación del Cancer-IBMCC, Spain

16:45-17:00

p53 regulated long non-coding RNA LINC00346 promotes cutaneous squamous cell carcinoma progression by regulating STAT3 and matrix metalloproteinase expression

Minna Piipponen

University of Turku, Finland 

17:00-17:30

Chronic inflammation and skin disease

Erwin Wagner

Centro Nacional de Investigaciones Oncológicas (CNIO), Spain

17:30-18:00

Break

18:00-18:30

Factors controlling stromal functions in wound healing and skin cancer

Sabine Werner

Eidgenössische Technische Hochschule Zurich (ETH), Switzerland

18:30-18:45

Roles of the nuclear receptors PPARs in skin responses to UV and skin cancers

Liliane Michalik

University of Lausanne (UNIL), Switzerland

18:45-18:50

CSL / Notch1 control genomic stability in cancer-associated fibroblast activation and expansion

Giulia Bottoni

University of Lausanne (UNIL), Switzerland & Massachusetts General Hospital (MGH), USA

18:50-18:55

Targeting Activin signaling pathway in SCC

Michael Cangkrama

Eidgenössische Technische Hochschule Zurich (ETH), Switzerland

18:55-19:00

Efficient cancer control with immune checkpoint blockade requires cytokine-induced senescence

Ellen Brenner

Dermatology, Eberhard Karls University Tübingen, Germany

19:00-19:30

An important role of the vasculature in skin cancer progression

Michael Detmar

Eidgenössische Technische Hochschule Zurich (ETH), Switzerland

20:00

Dinner

 

Session IV

Session IV: The pigment cell enigma

Chair: Martin Röcken & Liliane Michalik

08:30-09:00

Time and space trends in melanoma incidence and mortality: clues for understanding the etiology

Roberto Zanetti

International Association of Cancer Registries (IACR)

09:00-09:15

Reproductive factors, exogenous hormone use, and incidence of melanoma among women in the United States

Elizabeth Cahoon

U.S. National Cancer Institute, USA

09:15-09:45

Mechanisms underlying risk and pathogenesis of melanoma

David Fisher

Massachusetts General Hospital (MGH), USA

09:45-10:00

Subpopulations of melanoma cells with distinct biological properties exhibit varying levels of ZEB proteins 

Niels Vandamme

VIB – Inflammation Research Center, Belgium

10:00-10:30

Coffee break

10:30-11:00

Humanized mice: A model for melanocyte transformation and early melanoma progression

Shyam Somasundaram

The Wistar Institute, USA

11:00-11:30

Melanomas and their precursors

Boris Bastian

University of California San Francisco, USA

11:30-11:35

BRAFV600E in Primary and Recurrent Nevi and Melanomas

Nora Woltsche

Medical University of Graz, Austria 

11:35-11:40

Spontaneous and therapeutic STING activation in the skin melanoma microenvironment induces an efficient antitumor immune response

Dorys Adriana Lopez Ramos

Centre Hospitalier Universitaire Vaudois (CHUV), Switzerland

11:40-11:45

Unexpected contribution of lymphatic vessels to promotion of distant metastatic spread of melanoma

Qiaoli Ma

Eidgenössische Technische Hochschule Zurich (ETH), Switzerland

11:45-12:15

Clinical Raster Scan Optoacoustic Mesoscopy for skin imaging. Diving deep and staying focused

Juan Aguirre

Technische Universität München and Institute for Biological and Medical Imaging, Helmholtz Zentrum München, Germany

12:15-12:30

Comprehensively characterize complex tissues in spatial context with Imaging Mass Cytometry

Roberto Spada

Fluidigm

12:30-16:00

Lunch and poster session II

 

Session V

Session V: The interplay between immune cells and their neighbours

Chair: Maria Sibilia & Caterina Missero

16:00-16:30

Molecular changes in Actinic Keratosis and effects of treatment with photodynamic therapy

Francesca Zolezzi

GALDERMA

16:30-17:00

The impact of neutrophils in cutaneous leishmaniasis

Fabienne Tacchini-Cottier

University of Lausanne

17:00-17:30

Immune influences on early mutant keratinocyte clonal expansion

Michael Girardi

Yale School of Medicine, USA

17:30-18:00

Break

18:00-18:30

Key functional genomic events in the transformation of cutaneous T-cells

Sean Whittaker

King’s College London, UK

18:30-18:45

Epithelial damage and tissue gd T cells promote a unique tumor- protective IgE response

Jessica Strid

Imperial College London, UK

18:45-18:50

Simultaneous Multiplexed Imaging of mRNA and Proteins with Subcellular Resolution in Tissue Samples by Imaging Mass Cytometry

Daniel Schulz

Institute of Molecular Life Sciences/University of Zurich, Switzerland

18:50-19:20

Essential role of skin commensal bacteria in the wound healing response

Michel Gilliet

Centre Hospitalier Universitaire Vaudois – Université de Lausanne (CHUV-UNIL), Switzerland

20:00

Dinner and drinks

Session VI

Session VI: The skin ecosystem

Chair: Allan Balmain & Berna Özdemir

08:30-09:00

The influence of skin microbiota to skin inflammation

Maria Sibilia

Medical University of Vienna, Austria

09:00-09:15

UV and Cutaneous Papillomavirus Infection cooperate in Non-Melanoma Skin Cancer Development

Daniel Hasche

German Cancer Research Center (DKFZ), Germany

09:15-09:30

Melanoma-derived extracellular microvesicles are taken up by lymph node resident macrophages and lymphatic endothelial cells and induce lymph node remodeling

Lothar Dieterich

Eidgenössische Technische Hochschule Zurich (ETH), Switzerland

09:30-10:00

Role for the skin microbiota in tissue immunity and inflammation

Yasmine Belkaid

National Institutes of Health (NIH), USA

10:00-10:30

Coffee break

10:30-11:00

Role of the microenvironment in cancer invasion and therapy response

Erik Sahai

The Francis Crick Institute

11:00-11:15

Pitx1 controls a bi-stable transcriptional network that governs self-renewal and differentiation in Squamous Cell Carcinomas

Markus Schober

NYU School of Medicine, Department of Dermatology, USA

11:15-11:45

Highly multiplexed analysis of the tumor ecosystem on the single cell level by mass cytometry

Bernd Bodenmiller

Institute of Molecular Life Sciences, University of Zürich, Switzerland

11:45-12:00

Skin Cancer Prevention: meeting highlights and a look into the future

Barbara Gilchrest

Massachusetts General Hospital (MGH), USA